A new study indicates that consuming a larger portion of daily calories earlier in the day could help counter weight gain, stabilize blood sugar variations, and decrease the duration of elevated blood sugar levels.

“This type of feeding, through its effect on blood sugar, may prevent those with prediabetes or obesity from progressing to type 2 diabetes,” said study lead author Joanne H. Bruno, MD, PhD, an endocrinology fellow at NYU Langone Health.

Recently resented at the Endocrine Society’s annual meeting, the new report evaluated early time-restricted feeding (eTRF), which involves restricting calories to the first eight hours of the day. Previous studies have found this form of intermittent fasting may improve cardiometabolic health and blood sugar levels. However, the team wanted to determine whether these improvements were related to weight loss or the fasting strategy.

Led by researchers at NYU Grossman School of Medicine, the work is the first to evaluate the effects of early time-restricted feeding on glycemia and inflammation independent of weight loss.

Early time-restricted feeding (eTRF) improves glycemia and inflammatory markers even in the absence of weight loss. Credit: NYU Langone Health

For their study, the researchers compared eTRF (80 percent of calories consumed before 1 PM) to a usual feeding pattern (50 percent of calories consumed after 4 PM) among ten participants with prediabetes and obesity.

The patients were randomized to eTRF or usual feeding patterns for the first seven days and were changed over to the alternative arm for the next 7 days. Food was provided to meet the patients’ caloric needs for weight maintenance to determine the weight-independent effects of this strategy. Patients wore continuous glucose (blood sugar) monitors throughout the study.

Led by researchers at NYU Grossman School of Medicine, the work is the first to evaluate the effects of early time-restricted feeding on glycemia independent of weight loss. Credit: NYU Langone Health

“We decreased the time these individuals were having high blood sugar levels with just one week of eTRF feeding,” said study senior author Jose O. Aleman, MD, Ph.D., assistant professor in the Department of Medicine, Division of Endocrinology, Diabetes, & Metabolism at NYU Grossman School of Medicine. “The findings show that eating a majority of one’s calories earlier in the day reduces the time that the blood sugar is elevated, thereby improving metabolic health.”

Dr. Aleman and colleagues discovered the participants’ weights were stable throughout the study. Early time-restricted feeding led to a decreased mean amplitude of glycemic excursion and decreased time above range (blood glucose > 140mg/dL) compared to the usual eating pattern group. The time in range was similar between the eTRF and the usual feeding pattern group.

“Based on this data, eTRF may be a helpful dietary strategy for diabetes prevention,” concluded Dr. Bruno. “Further studies are needed to understand the true overall benefit of these intervention strategies.”

Meeting: ENDO 2023, the Endocrine Society’s annual meeting

Funding for the study was provided by the National Heart, Lung and Blood Institute Institutional Training grant T32HL098129 and National Institutes of Health grant K08 DK117064. Further funding was provided by Rockefeller University’s Shapiro Silverberg Fund for the Advancement of Translational Research.

In addition to Dr. Bruno and Dr. Aleman, other NYU Langone researchers involved in the study were Shabnam Nasserifer, MD; Sally Vanegas, PhD; and Collin Popp, PhD.